Table 3 Biological pathways with increased glutamine or glutamate influx across 11 types of cancer
From: Systematic analyses of glutamine and glutamate metabolisms across different cancer types
| Pathway | Substrate → product | Cancer type(s) |
|---|---|---|
| Purine/pyrimidine metabolisms | Glutamine → nucleotides | BRCA, KIRC |
| Biomass production | Glutamine → biomass | PRAD, THCA |
| UDP-GlcNAc metabolism | Glutamine → UDP-GlcNAc | BRCA, PRAD |
| Asparagine metabolism | Glutamine → asparagine | BLCA, LUAD |
| Proline metabolism | Glutamine → proline | PRAD |
| Serine metabolism | Glutamate → serine | BLCA |
| GSH metabolism | Glutamate → GSH | BRCA, KICH, LUAD |